The reference site for Chlorothiazide

Chlorothiazide sodium (Diuril) is an organic compound used as a diuretic and as an antihypertensive.

WHAT IS Chlorothiazide?

Chlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

This medicine treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, kidney disorders, or edema caused by taking steroids or estrogen. This medication is also used to treat high blood pressure (hypertension).

 

Brand Name(s): Diurigen; Diuril
CAS nº: 58-94-6
(klor o THY a zide)

 

Product Info

The sections below will provide you with more specific information and guidelines related to chlorothiazide and its correct use. Please read them carefully.

FDA Information

Chlorothiazide was approved by the FDA in 1957. A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Chlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

This medicine treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, kidney disorders, or edema caused by taking steroids or estrogen. This medication is also used to treat high blood pressure (hypertension).

Mechanism of Action:
Thiazide diuretics increase the excretion of water by inhibiting the reabsorption of sodium and chloride ions at the distal renal tubule. The natriuretic effects are accompanied by a secondary loss of potassium and bicarbonate which can cause a mild hypokalemic, hypochloremic, metabolic alkalosis. Thiazides also decrease the elimination of calcium and uric acid. Thiazides diuretics usually do not affect normal blood pressure. When chronically administered, diuretics decrease peripheral vascular resistance. The exact mechanism responsible for the lowered peripheral resistance is not known, however, excretion of urinary sodium by the kidneys is required to achieve blood pressure reduction.

Initially, diuretics lower blood pressure by decreasing cardiac output, plasma volume and extracellular fluid volume. Cardiac output eventually returns to normal, plasma and extracellular fluid values return to slightly less than normal, but peripheral vascular resistance is reduced, resulting in lower blood pressure. Thiazide diuretics also decrease the glomerular filtration rate, which contributes to the drug’s lower efficacy in patients with renal impairment. The changes in plasma volume induce an elevation in plasma renin activity and aldosterone secretion which contributes to the potassium losses associated with thiazide diuretics. In general, diuretics can worsen LVH, glucose tolerance, and lipid abnormalities.

Other uses for this medicine

Chlorothiazide may also be used to treat patients with diabetes insipidus and certain electrolyte disturbances, and to prevent kidney stones in patients with high levels of calcium in their blood.

However, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Chlorothiazide comes in tablet and liquid form which is to be taken orally. It is usually taken once or twice a day. If you are to take it once a day, take it in the morning, and if you are to take it twice a day, take it in the morning and in the late afternoon to avoid going to the bathroom during the night.

Take this medication exactly as it was prescribed to you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Chlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using a thiazide diuretic.

Additionally, if you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.

What special precautions should I follow?

BEFORE TAKING CHLOROTHIAZIDE:

Be sure to inform your doctor if you have kidney disease, liver disease, asthma or allergies, gout, lupus or diabetes. If you have any of these conditions, you may not be able to use chlorothiazide, or you may need a dosage adjustment or special tests during treatment.

Avoid using other medicines that make you light-headed (narcotic pain medication, muscle relaxers, and medicine for seizures). They can add to the side effects of chlorothiazide.

Do not use this medication if you are unable to urinate or if you have an allergy to sulfa drugs.

Moreover, chlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using a thiazide diuretic.

This medication falls under the FDA pregnancy category C. This means that it may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Furthermore, chlorothiazide can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Avoid drinking alcohol, which can increase some of the side effects of chlorothiazide.

Additionally, avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor’s instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time.

Never take extra medicine to make up the missed dose.

What side effects can this medication cause?

Get emergency medical help if you have any of these signs of an allergic reaction:

hives
difficulty breathing
swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

dry mouth or thirst
nausea
vomiting
feeling weak, drowsy, restless, or light-headed
fast or uneven heartbeat
muscle pain or weakness
urinating less than usual or not at all
red or purple spots on your skin
numbness or tingly feeling
a red, blistering, or peeling skin rash
stomach pain, low fever, or loss of appetite
dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes)

Continue using chlorothiazide and talk with your doctor if you have any of these less serious side effects:

dizziness
headache
muscle spasm
blurred vision

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medicine in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not let the oral liquid freeze.

Please remember to throw away any medicine that is outdated or no longer needed, and talk to your pharmacist about the proper disposal of your medicine.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, please call the local emergency services on 911.

Symptoms of overdose may include:

nausea
weakness
dizziness
dry mouth
thirst
muscle pain or weakness

Product Images

PICTURES OF CHLOROTHIAZIDE PRODUCTS

Below you will find images and specific information on the principal types of chlorothiazide that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: DIURIL®
Strength(s): 250 MG
Imprint: DIURIL | MSD 214
Manufacturer: MERCK & CO.

Name: DIURIL®
Strength(s): 250 MG / 5ML
Imprint: DIURIL (CHLOROTHIAZIDE)
Manufacturer: MERCK & CO.

Name: CHLOROTHIAZIDE
Strength(s): 500 MG
Imprint: MYLAN 162
Manufacturer: MYLAN

Name: DIURIL®
Strength(s): 500 MG
Imprint: DIURIL | MSD 432
Manufacturer: MERCK & CO.

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